How can I compare different antipsychotics? 

This page has tables to help you compare antipsychotics by different factors. These are: 

  • generic name and key characteristics 
  • type of antipsychotic (first or second generation) 
  • half-life 
  • form available 
  • dietary considerations 

Why might I want to compare antipsychotics?

Understanding more about the different antipsychotics available may help you talk to your doctor or psychiatrist about what’s right for you, including: 

  • If you’ve experienced problems with a particular type of antipsychotic and want to avoid them. For example, if you’ve experienced problems with a first generation (older)  antipsychotic and want to change to a newer drug. 
  • If you need your medication in a different form. For example, you may have problems with swallowing or find it hard to remember to take your medication correctly every day. 
  • If you have any dietary restrictions, such as being vegetarian or intolerant to some ingredients. 
  • If the drug’s half-life is important to you. For example, if you are concerned about withdrawal effects and would prefer a drug with a longer half-life. For information about  what the half-life means and why it matters, see our page about medication half-life. 
  • If you are worried about certain side effects of your medication. 

Remember: drugs don’t work the same way for everyone, and it’s important to find a medication  that works for you. See our page on receiving the right medication for more information. 

Antipsychotics by generic name and key characteristics 

Each of these drugs may be known by several different names, which we have listed below under  the Generic name and Trade names columns.

Generic name Trade names (UK) Type of antipsychotic Forms available Half-life Dietary considerations
amisulpride Amisulpride Normon, Amisulpride Rivopharm, Amisulpride Sandoz, Solian, Vick-Amisulpride  2nd generation
  • tablets
about 12 hrs tablets contain lactose
aripiprazole Abilify Discmelt, Abilify, Aripiprazol Stada, Aripiprazole Actavis, Aripiprazole Normon, Aripiprazole Sandoz, Aripizo, Aryzalera 2nd generation
  • tablets
  • dissolving tablets
  • emergency injection
75–146 hrs tablets contain lactose (dissolving tablets do not)
aripiprazole Abilify Maintena 2nd generation depot 30–47 days none
chlorpromazine Chlozine 1st generation
  • tablets
20–40 hrs tablets contain lactose
clozapine Clopine, Clozapine, Clozarem, Clozaril, Vick-Clozapine  2nd generation
  • tablets
6–26 hrs contains lactose
flupentixol Vick-Flupentixol 1st generation
  • tablets
about 35 hrs contains lactose
flupentixol decanoate Flupentixol – Neuraxpharm  1st generation depot about 21 days contains coconut oil
fluphenazine decanoate Fluphenazine- Neuraxpharm  1st generation depot 6–9 days contains sesame oil
haloperidol Apo-Haloperidol, Binin-U, Haldol, Haloper, Haloperidol Kern, Halpidol  1st generation about 20 hrs tablets contain lactose
haloperidol decanoate Haldol-Neuraxpharm, Haldol Decanoas  1st generation depot about 21 days contains sesame oil
lurasidone Latuda 2nd generation
  • tablets
20–40 hrs none
olanzapine Apo-Olanzapine, Apt-Olanzapine, Hovid Olanzapine, Nykob, Olanza, Olanzapin Tad, Olanzapine Sandoz, Alanzapine Stada, Olanzapine-Teva, Olza, Onzapin, Ozapex, Prenixa, Zylanza, Zyprexa, Zyprexa Zydis 2nd generation
  • tablets
  • dissolving tablets 
  • emergency injection
32–52 hrs

tablets contain lactose

(dissolving tablets do not)

olanzapine pamoate monohydrate ZypAdhera 2nd generation depot about 30 days none
paliperidone

Invega

Pamoprex

2nd generation
  • slow release tablets
about 23 hrs 3mg tablets contain lactose
paliperidone palmitate Invega Sustenna, Invega Trinza 

2nd generation

depot

25–49 days none
pericyazine Neulactil, Vick-Pericyazine 1st generation
  • tablets
about 12 hrs tablets contain lactose
pimozide Vick-Pimozide  1st generation
  • tablets
about 55 hrs none
prochlorperazine Metil, Nautisol, Pemazil, Peratil, Prochlor, Prochlorperazine Maleate, Protil, Seratil, Stemetil 1st generation 4–8 hrs tablets contain lactose
promazine Chlozine  1st generation
  • tablets
not available tablets contain lactose
quetiapine

Accord Quetiapine,  

Alvoquel 

Apo- Quetiapine, PMS-Quetiapine, Quantia, Quesero, Quetiapine Sandoz, Quetiapine Tevapharm, Quetiapine-Teva,, 

Serogen, Seroquel, Seroquel XR, 

Setinin 

2nd generation
  • tablets
  • slow release tablets
7–12 hrs contains lactose
sulpiride Gamotil, Sulide, Sulpidyl, Sulpiren, Supide, Vick-Sulpride 1st generation
  • tablets
  • capsules
about 8 hrs tablets contain lactose
trifluoperazine Apo-Trifluoperazine  1st generation
  • tablets
about 22 hrs tablets contain gelatin
ziprasidone  Zeldox, Ziprasidon Stada, Zypsila  2nd generation 
  • capsules 
6-7 hours  none
zuclopentixol decanoate Clopixol 1st generation depot about 19 days contains thin vegetable oil
zuclopenthixol dihydrochloride Clopixol 1st generation
  • tablets
about 24 hrs contains lactose

 

Antipsychotics by type

Type of antipsychotic Antipsychotics in this type
1st generation 
  • flupentixol
  • haloperidol
  • pericyazine
  • pimozide
  • prochlorperazine
  • promazine
  • sulpiride
  • trifluoperazine
  • zuclopenthixol dihydrochloride
1st generation depot
  • flupentixol decanoate
  • fluphenazine decanoate
  • haloperidol decanoate
  • zuclopentixol decanoate
2nd generation 
  • amisulpride
  • aripiprazole
  • clozapine
  • lurasidone
  • olanzapine
  • paliperidone
  • quetiapine
  • ziprasidone
2nd generation depot
  • aripiprazole
  • olanzapine pamoate monohydrate
  • paliperidone palmitate 

 

Antipsychotics by half-life

Half-life  Antipsychotic
4–9 hours  prochlorperazine
6–26 hours  clozapine
6 – 7 hours  ziprasidone 
7–12 hours  quetiapine
about 8 hours  sulpiride
about 12 hours  amisulpride
about 12 hours  pericyazine
20–40 hours  lurasidone
20–40 hours  promazine
21–24 hours  haloperidol
about 22 hours  trifluoperazine
about 23 hours  paliperidone
about 24 hours  zuclopenthixol dihydrochloride
about 30 hours  chlorpromazine
31–52 hours  olanzapine
about 35 hours  flupentixol
55–150 hours  pimozide
75–146 hours  aripiprazole
2–8 days  cariprazine
17–112 days  fluphenazine decanoate
17–21 days  flupentixol decanoate
about 19 days  zuclopentixol decanoate
about 21 days  haloperidol decanoate
25–139 days  paliperidone palmitate
29–46 days  aripiprazole (depot)
about 30 days  olanzapine pamoate monohydrate

 

Antipsychotics by form available

Form  Antipsychotics available in this form
tablets 
  • amisulpride
  • aripiprazole
  • chlorpromazine
  • clozapine
  • flupentixol
  • haloperidol
  • lurasidone
  • olanzapine
  • paliperidone
  • pericyazine
  • pimozide
  • prochlorperazine
  • promazine
  • quetiapine
  • sulpiride
  • trifluoperazine
  • zuclopenthixol dihydrochloride
dissolving tablets 
  • aripiprazole
  • clozapine
  • olanzapine
capsules 
  • cariprazine
liquid 
  • haloperidol
  • pericyazine
injection
  • aripiprazole
  • flupentixol decanoate
  • fluphenazine decanoate
  • haloperidol
  • haloperidol decanoate
  • olanzapine
  • olanzapine pamoate monohydrate
  • paliperidone palmitate
  • prochlorperazine
  • zuclopentixol decanoate

 

Antipsychotics by dietary considerations 

Certain brands of individual drugs may have other dietary restrictions that aren’t listed in the tables  below. If you are concerned about this, you can check the Drug Information Leaflet  included in the box with your medication. This will include a section listing the ingredients contained in your medication.

Dietary consideration Drugs this applies to
Contains lactose
  • amisulpride
  • aripiprazole
  • chlorpromazine
  • clozapine
  • flupentixol
  • haloperidol
  • olanzapine (non-dissolving tablets only)
  • paliperidone (3mg tablets only)
  • pericyazine
  • prochlorperazine
  • promazine
  • quetiapine (some tablets)
  • sulpiride
  • zuclopenthixol dihydrochloride
Contains gelatine
  • risperidone (some tablets)
  • trifluoperazine
  • cariprazine
  • chlorpromazine (tablets only)
Contains coconut oil
  • flupentixol decanoate
  • zuclopenthixol
Contains sesame oil
  • fluphenazine decanoate
  • haloperidol decanoate
  • pipotiazine palmitate
Contains vegetable oil
  • zuclopenthixol decanoate

 

Previous page Next page