What are antipsychotics? 

Antipsychotics are a type of psychiatric medication which are available on prescription to treat  psychosis. They are licensed to treat certain types of mental health problems whose symptoms  include psychotic experiences. This includes: 

  • schizophrenia 
  • schizoaffective disorder 
  • some forms of bipolar disorder 
  • severe depression 
  • the psychotic symptoms of a personality disorder. 

Some antipsychotics are also licensed to treat other health problems, including: 

  • physical problems, such as persistent hiccups, problems with balance and nausea (feeling  sick) 
  • agitation and psychotic experiences in dementia. This is only recommended if you pose a risk  to yourself or others, or if you are severely distressed. 

Antipsychotics can be prescribed to be taken in various different ways. Most commonly you will take  them by swallowing them, in tablet or liquid form. But some of them can also be prescribed as a depot injection. This is a slow-release, slow-acting form of the medication, given as an injection  every few weeks. 

Who can prescribe antipsychotics? 

The healthcare professionals who can prescribe you antipsychotics include: 

  • a psychiatrist 
  • your family doctor

When you are first prescribed antipsychotics, this is usually done by a psychiatrist. Your family doctor can also sometimes give your first prescription. But they are more likely to give you ongoing prescriptions, once  you are already taking the medication. 

These information pages refer to ‘your doctor or psychiatrist’, as they are the most likely people to  prescribe you an antipsychotic.

How do antipsychotics work? 

Antipsychotic drugs don’t cure psychosis but they can help to reduce and control many psychotic  symptoms, including: 

  • delusions and hallucinations, such as paranoia and hearing voices 
  • anxiety and serious agitation, for example from feeling threatened 
  • incoherent speech and muddled thinking 
  • confusion 
  • violent or disruptive behaviour 
  • mania. 

Antipsychotics might not get rid of these symptoms completely but they may help you stop feeling so bothered by them. The aim is to help you feel more stable, so you can lead your life the way you want  to. Taking antipsychotics can also reduce the risk of these symptoms returning in the future (relapse). 

You may find that some types of antipsychotics work better than others for your symptoms. Or you  may find that antipsychotics aren’t right for you. See our page on how antipsychotics can help to find  out more. 

“They make me feel calm, help me sleep, stop racing thoughts and help blunt hallucinations. Meds  don’t make life perfect – they just help me cope with the imperfections and struggles I face.” 

What’s the science behind antipsychotics? 

There are several possible explanations why antipsychotic drugs may help to reduce psychotic  symptoms: 

  • Blocking the action of dopamine. Some scientists believe that certain psychotic experiences  are caused by your brain producing too much of a chemical called dopamine. Dopamine is a  neurotransmitter, which functions to pass messages around your brain. Most  antipsychotic drugs are known to block some of the dopamine receptors in the brain. This  reduces the flow of these messages, which can help to reduce your psychotic symptoms. 
  • Affecting other brain chemicals. Most antipsychotics are known to affect other brain  chemicals too. This may include the neurotransmitters serotonin, noradrenaline, and  glutamate. These chemicals are thought to be involved in regulating your mood. 

Antipsychotics may help to relieve psychotic symptoms by causing changes to your brain chemistry.  But the causes of psychosis can be very complex, and may be affected by your life experiences and  your environment as much as the chemicals in your brain. 

Talking therapy is a treatment option for your psychosis. In some cases, they might help you understand the causes of the illness, and also develop ways to better manage the symptoms. 

What different types of antipsychotic are there? 

Antipsychotic drugs tend to fall into one of two categories: 

  • first generation (older), or ‘typical’ antipsychotics 
  • second generation (newer), or ‘atypical’ antipsychotics. 

Both types can potentially work for different people. They also have different side effects. 

First generation (older) antipsychotics 

Key facts: 

  • These are sometimes referred to as ‘typicals’. 
  • They are divided into various chemical groups which all act in a very similar way and can therefore cause  very similar side effects, including severe neuromuscular side effects. 
  • But they are not all the same. For example, some may cause more severe movement  disorders than others, or be more likely to make you more drowsy. 

Second generation (newer) antipsychotics 

Key facts: 

  • These are sometimes referred to as ‘atypicals’. 
  • In general, they cause less severe neuromuscular side effects than first generation  antipsychotics. 
  • Some are also less likely to cause sexual side effects compared to first generation  antipsychotics. 
  • But second generation antipsychotics may be more likely to cause serious metabolic side  effects. This may include rapid weight gain and changes to blood sugar levels. 

The side effects that you may experience from drugs in either group will vary, depending on your  dose and how you respond to the drug that you are prescribed. 

“I still take antipsychotic medication today and I don’t have a problem with it. I feel so much better than when I was first prescribed an antipsychotic. I know that they work for me and help.” 

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